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Did you mean r ras and embryonic tissues (54 results)?
R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.
Herrera JL, Komatsu M. Herrera JL, et al. J Vasc Res. 2021;58(4):252-266. doi: 10.1159/000514555. Epub 2021 Apr 19. J Vasc Res. 2021. PMID: 33873190 Free PMC article.
We investigated the specific contribution of pericyte-expressed R-Ras to the development of the retinal vasculature. METHODS: The effect of R-Ras deficiency in pericytes was analyzed in pericyte-targeted conditional Rras knockout mice at birth and duri …
We investigated the specific contribution of pericyte-expressed R-Ras to the development of the retinal vasculature. METHODS: …
Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels.
Sawada J, Urakami T, Li F, Urakami A, Zhu W, Fukuda M, Li DY, Ruoslahti E, Komatsu M. Sawada J, et al. Cancer Cell. 2012 Aug 14;22(2):235-49. doi: 10.1016/j.ccr.2012.06.013. Cancer Cell. 2012. PMID: 22897853 Free PMC article.
The genetic disruption of R-Ras severely impaired the maturation processes of tumor vessels in mice. ...Thus, R-Ras promotes normalization of the tumor vasculature. These findings identify R-Ras as a critical regulator of vessel integrity …
The genetic disruption of R-Ras severely impaired the maturation processes of tumor vessels in mice. ...Thus, R-Ras …
Prostaglandin E2 breaks down pericyte-endothelial cell interaction via EP1 and EP4-dependent downregulation of pericyte N-cadherin, connexin-43, and R-Ras.
Perrot CY, Herrera JL, Fournier-Goss AE, Komatsu M. Perrot CY, et al. Sci Rep. 2020 Jul 7;10(1):11186. doi: 10.1038/s41598-020-68019-w. Sci Rep. 2020. PMID: 32636414 Free PMC article.
Prostaglandin E2 (PGE2) is a lipid mediator of inflammation, and its tissue concentration is elevated in cancer and neurological disorders. ...N-cadherin and connexin-43 in adherens junction and gap junction between pericytes and ECs are downregulated by EP-4 and EP-1-depe …
Prostaglandin E2 (PGE2) is a lipid mediator of inflammation, and its tissue concentration is elevated in cancer and neurological diso …
Activation of PI3K and R-Ras signaling promotes the extension of sensory axons on inhibitory chondroitin sulfate proteoglycans.
Silver L, Michael JV, Goldfinger LE, Gallo G. Silver L, et al. Dev Neurobiol. 2014 Sep;74(9):918-33. doi: 10.1002/dneu.22174. Epub 2014 Mar 27. Dev Neurobiol. 2014. PMID: 24578264 Free PMC article.
Expression of constitutively active R-Ras promoted axon extension and growth cone elaboration on CSPGs and permissive substrata. ...These data indicate that activation of R-Ras-PI3K signaling may be a viable approach for manipulating axon extension on …
Expression of constitutively active R-Ras promoted axon extension and growth cone elaboration on CSPGs and permissive substrat …
H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesis.
Pozzi A, Coffa S, Bulus N, Zhu W, Chen D, Chen X, Mernaugh G, Su Y, Cai S, Singh A, Brissova M, Zent R. Pozzi A, et al. Mol Biol Cell. 2006 Apr;17(4):2046-56. doi: 10.1091/mbc.e05-08-0800. Epub 2006 Feb 8. Mol Biol Cell. 2006. PMID: 16467383 Free PMC article.
Although members of the Ras GTPase family control cell growth, differentiation, proliferation, and migration, their role in development of the collecting system of the kidney is unexplored. In this study, we demonstrate that members of the R-Ras family of proteins, …
Although members of the Ras GTPase family control cell growth, differentiation, proliferation, and migration, their role in development of t …
Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor.
Radha V, Mitra A, Dayma K, Sasikumar K. Radha V, et al. Biosci Rep. 2011 Aug;31(4):231-44. doi: 10.1042/BSR20100094. Biosci Rep. 2011. PMID: 21366540 Review.
C3G (Crk SH3-domain-binding guanine-nucleotide-releasing factor) is a ubiquitously expressed member of a class of molecules called GEFs (guanine-nucleotide-exchange factor) that activate small GTPases and is involved in pathways triggered by a variety of signals. It is essential …
C3G (Crk SH3-domain-binding guanine-nucleotide-releasing factor) is a ubiquitously expressed member of a class of molecules called GEFs (gua …
A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A.
Dodelet VC, Pazzagli C, Zisch AH, Hauser CA, Pasquale EB. Dodelet VC, et al. J Biol Chem. 1999 Nov 5;274(45):31941-6. doi: 10.1074/jbc.274.45.31941. J Biol Chem. 1999. PMID: 10542222 Free article.
Using a yeast two-hybrid screen, we have identified a novel signaling intermediate, SHEP1 (SH2 domain-containing Eph receptor-binding protein 1), which is expressed in the embryonic and adult brain. SHEP1 contains an Src homology 2 domain that binds to a conserved tyrosine …
Using a yeast two-hybrid screen, we have identified a novel signaling intermediate, SHEP1 (SH2 domain-containing Eph receptor-binding protei …
Transcription factor 8 activates R-Ras to regulate angiogenesis.
Inuzuka T, Tsuda M, Kawaguchi H, Ohba Y. Inuzuka T, et al. Biochem Biophys Res Commun. 2009 Feb 6;379(2):510-3. doi: 10.1016/j.bbrc.2008.12.101. Epub 2008 Dec 29. Biochem Biophys Res Commun. 2009. PMID: 19116136 Free article.
Tube formation by human umbilical vein endothelial cells (HUVECs) facilitated by TCF8 suppression was significantly inhibited by the expression of constitutive active mutant of R-Ras. When we examined the mRNA expression levels of R-Ras regulators, no …
Tube formation by human umbilical vein endothelial cells (HUVECs) facilitated by TCF8 suppression was significantly inhibited by the express …
Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism.
Molina-Ortiz P, Orban T, Martin M, Habets A, Dequiedt F, Schurmans S. Molina-Ortiz P, et al. PLoS Genet. 2018 Jan 30;14(1):e1007195. doi: 10.1371/journal.pgen.1007195. eCollection 2018 Jan. PLoS Genet. 2018. PMID: 29381707 Free PMC article.
Rasa3 is a GTPase activating protein of the GAP1 family which targets R-Ras and Rap1. Although catalytic inactivation or deletion of Rasa3 in mice leads to severe hemorrhages and embryonic lethality, the biological function and cellular location of Rasa3 unde …
Rasa3 is a GTPase activating protein of the GAP1 family which targets R-Ras and Rap1. Although catalytic inactivation or delet …
[Apoptosis and anti-apoptosis genes in the Bcl-2 family].
Dietrich JB. Dietrich JB. Arch Physiol Biochem. 1997 Apr;105(2):125-35. doi: 10.1076/apab.105.2.125.12927. Arch Physiol Biochem. 1997. PMID: 9296841 Review. French.
However, the understanding of the molecular pathways which regulate programmed cell death is more recent and far from complete. Apoptosis occurs during embryonic and foetal development, and tissue remodeling, and its purpose is to assure homeostasis of cells and …
However, the understanding of the molecular pathways which regulate programmed cell death is more recent and far from complete. Apoptosis oc …
15 results